Tag Archives: dementia

Journal of Alzheimer’s Disease

Issue: Volume 5, Number 4 / 2003
Pages: 267 – 269

Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia
M.J. Gillett A1, R.N. Martins A2, R.M. Clarnette A3, S.A.P. Chubb A4, D.G. Bruce , B.B. Yeap
A1 Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia, Australia
A2 Sir James McCusker Alzheimer’s Disease Research Unit, Hollywood Private Hospital and School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
A3 Department of Community and Geriatric Medicine, Fremantle Hospital, Australia
A4 Biochemistry Department, Fremantle Hospital, Australia
A5 School of Medicine and Pharmacology, University of Western Australia, Australia
In a group of 28 older men with either subjective memory loss or dementia, serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40 (Ag40, r=-0.5, P=0.01 and r=-0.4, P=0.04, respectively). Calculated free testosterone was also inversely correlated (r=-0.4, P=0.03), and all three relationships remained statistically significant after allowing for age. A similar but non-significant trend was seen with dehydroepiandrosterone sulphate (DHEAS), and neither luteinising hormone (LH) nor estradiol correlated with Ag40. These data demonstrate that lower androgen levels are associated with increased plasma Ag40 in older men with memory loss or dementia, suggesting that subclinical androgen deficiency enhances the expression of Alzheimer’s disease-related peptides in vivo. An inverse correlation exists between SHBG and Ag40, warranting further investigation.