San Diego Anti-aging medicine and family practice located in Encinitas CA, Center for Age Management

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Center for Age Management

317 N. El Camino Real, Suite 206
Encinitas, CA 92024
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Phone: 760-633-1315


Mon - Thur: 9am to 5pm
Lunch: 12pm to 1:30pm
Friday: 9am to 12pm
On Fridays, we will have limited staff. You may leave a message and it will be our pleasure to return your call. Any prescriptions, questions or concerns that you have, we will be happy to assist you Monday - Thursday.

Serving other neighboring cities: La Costa, Solana Beach, Rancho Santa Fe, Del Mar, San Marcos, Carlsbad, La Jolla, and San Diego County, CA.

Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.

Sent from my iPadMech Ageing Dev. 2009 NovDec;130(1 1-12):771-6.
Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy

_l$_, Brimacombe M, Nawrot TS,§tgessen JA, Pollak l\/N, Aviv A.
Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza
Miraglia 2, 80138 Naples, Italy.
Nbtations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels oflGF-1 in humans are associated with aging- related diseases and diminished longevity. As leukocyte telomere length (l_TL) is ostensibly a biomarker of human aging, we examined the relationship between LTl_ and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. We measured L’l’L by Southem blots and IGF-1 by enzyme- linked immunoassay. Both IGF-1 and LTl_ diminished with age (lGF-1, |=-0.601, P<0.001; LTl_, r=-0.706, P<0.001). Age-adjlsted LTL was positively associated with IGF-1 level throughout the age range of the cohort (r=0270, P<0.001). IGF-1 accounted for about 10% of the interindividual variation in LTL over ant above the effect of age. Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans. Further research will be necessary to establish whether LTl_ will ultimately be used in clinical settings as an index of healthy aging.