San Diego Anti-aging medicine and family practice located in Encinitas CA, Center for Age Management

Optimize Your Health
Center for Age Management

317 N. El Camino Real, Suite 206
Encinitas, CA 92024
USA View Map

Phone: 760-633-1315


Mon - Thur: 9am to 5pm
Lunch: 12pm to 1:30pm
Friday: 9am to 12pm
On Fridays, we will have limited staff. You may leave a message and it will be our pleasure to return your call. Any prescriptions, questions or concerns that you have, we will be happy to assist you Monday - Thursday.

Serving other neighboring cities: La Costa, Solana Beach, Rancho Santa Fe, Del Mar, San Marcos, Carlsbad, La Jolla, and San Diego County, CA.

Cortisol Levels During Aging

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

Sonia J. Lupien1,2, Mony de Leon3, Susan de Santi3, Antonio Convit3, Chaim Tarshish3, N.P.V.
Nair1, Mira Thakur1, Bruce S. McEwen4, Richard L. Hauger5 and Michael J. Meaney1

Correspondence should be addressed to S.J.L. (
Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual
deficits in spatial learning in aged rats. Previously we related persistent cortisol increases to memory
impairments in elderly humans studied over five years. Here we demonstrate that aged humans with
significant prolonged cortisol elevations showed reduced hippocampal volume and deficits in
hippocampus-dependent memory tasks compared to normal-cortisol controls. Moreover, the degree
of hippocampal atrophy correlated strongly with both the degree of cortisol elevation over time and
current basal cortisol levels. Therefore, basal cortisol elevation may cause hippocampal damage and
impair hippocampus-dependent learning and memory in humans.

To read more on this article, download PDF Cortisol Levels during Aging