Category Archives: Growth Hormone

Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.

Brimacombe M, Nawrot TS,§tgessen JA, Pollak l\/N, Aviv A.
Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza
Miraglia 2, 80138 Naples, Italy.
Abstract
Nbtations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels oflGF-1 in humans are associated with aging- related diseases and diminished longevity. As leukocyte telomere length (l_TL) is ostensibly a biomarker of human aging, we examined the relationship between LTl_ and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southem Italy. We measured L’l’L by Southem blots and IGF-1 by enzyme- linked immunoassay. Both IGF-1 and LTl_ diminished with age (lGF-1, |=-0.601, P<0.001; LTl_, r=-0.706, P<0.001). Continue reading

Hgh sand Alzheimer’s IGF-1 Deficiency Possible Contributor to Alzheimer’s in Men

From: Andrea
Date: December 1, 2012 9:16:55 AM PST
To: colerai4b@hpeprint.com
Subject: Hgh sand Alzheimer’s
IGF-1 Deficiency Possible Contributor to Alzheimer’s in Men Journal of Clinical Endocrinology & Metabolism reports that low levels of Insulin Like Growlh Factor linked to Alzheimer’s in men but not in women. Continue reading

The lGF-1IlGF-1R signaling axis in the skin

The lGF-1IlGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer.
Lewis DA, Travers JB, Somani AK, .
Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Abstract
The appropriate response of human keratinocytes to ultraviolet-B (UVB) is dependent on the activation status of the insulin-like growth factor 1 (lGF-1) receptor. Keratinocytes Ql’OWfl in conditions in which the IGF-1 receptor is inactive inappropriately replicate in the presence of UVB-induced DNA damage. Continue reading

A Randomized, Placebo-Controlled Trial

Howard B.A. Baum, MD; Beverly M.K. Biller, MD; Joel S. Finkelstein, MD;
Kristin Baker Cannistraro, BS, RN; Daniel S. Oppenheim, MD, PhD; David A. Schoenfeld, PhD; Theresa
Hoskins Michel, PT, MS; Harriet Wittink, PT, MS; and Anne Klibanski, MD
‘ Background: Patients with adultonset growth hormone deficiency have reduced bone density and increased fat mass. Growth hormone at high doses may decrease body fat in these patients, but the effects of growth hormone at more physiologic doses on bone density and body compo- sifion have not been convincingly shown.
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Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.

Sent from my iPadMech Ageing Dev. 2009 NovDec;130(1 1-12):771-6.
Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy
subjects.

_l$_, Brimacombe M, Nawrot TS,§tgessen JA, Pollak l\/N, Aviv A.
Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Piazza
Miraglia 2, 80138 Naples, Italy.
Abstract
Nbtations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels oflGF-1 in humans are associated with aging- related diseases and diminished longevity. As leukocyte telomere length (l_TL) is ostensibly a biomarker of human aging, we examined the relationship between LTl_ and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. Continue reading

Growth hormone releasing hormone improves the cognition of healthy older adults.

Neurobiol Agigg. 2006 Feb;27(2):318-23. Epub 2005 Mar 23.

Vitiello MV, Moe KE, Merriam GR, Mazzoni G, Buchner DH, Schwartz RS.
Department of Psychiatry and Behavioral Sciences, BB-1520D Health Science Building, University of Washington, Box 356560, 1959 NE Pacific Street, Seattle, WA 98195-6560, USA. vitielIo@u.washington.edu
Abstract
Declines in the activity of the somatotrophic axis have been implicated in the age-related changes observed in a number of physiological functions, including cognition. Continue reading

Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults.

Woodhouse LJ, Asa SL, Thomas SG, Ezzat S.

Department of Physical Therapy, The University of Toronto, Ontario, Canada.

The impact of GH on functional performance in GH-deficient adults is not well understood. To investigate the effects of GH on skeletal muscle, physical, and functional capacity, we randomized 28 GH-deficient adults to receive 3 months of recombinant human GH [rhGH: somatotropin, 6.25 microg/kg lean body mass (LBM) for 1 month, 12.5 microg/kg LBM thereafter] in a double-blind placebo-controlled crossover trial. We measured muscle fiber type, size, and insulin-like growth factor I messenger RNA, aerobic capacity [maximal oxygen uptake (VO2max), ventilation threshold (VeT)], isokinetic strength, oxygen-cost-of-walking at normal and fast speeds, and fatigue determined by the profile of mood states questionnaire. Continue reading

Effect of human growth hormone on human pancreatic carcinoma growth, protein, and cell cycle kinetics

J Surg Res. 1996 Mar;61(2):317-22.

Harrison LE, Blumberg D, Berman R, Ng B, Hochwald S, Brennan MF, Burt M.

Surgical Metabolism Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

The role of human growth hormone (hGH) as a nutritional adjunct for cancer patients is controversial because of its potential mitogenic effects on tumor growth. No studies to date have examined the effect of hGH on human tumor response in vivo. In Vitro: Athymic mice were injected (s.c.) daily with hGH (GH, n=14) or saline (CTL, n=14). On Day 10, serum was collected and added to human pancreatic carcinoma cells in culture. In Vivo: Athymic mice were inoculated (s.c.) with human pancreatic carcinoma cells. Continue reading

Effects of 6 Years Of Growth Hormone (GH) Treatment

Effects of 6 Years Of Growth Hormone (GH) Treatment On Bone Mineral Density In GH-Deficient Adults
OBJECTIVE: Adults with growth hormone (GH) deficiency are often osteopenic. Short-term GH replacement therapy has been shown to improve bone mineral density (BMD). However, whether the increases in BMD are progressive with time is still unclear. We therefore examined long-term changes in BMD with GH treatment in GH-deficient adults over a period of 6 years.
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